Not much to look for at all, other than the colour you want ::008::
No major issues or flaws, in fact not sure there are even any minor ones on the 2014+ models.
Spokes tarnish over time even if the bike is quite well looked after, and will go horrible fairly quickly if they are not pampered, mine are still fairly good at 3 years / 18000 miles but losing the shine in places.
I had a 1200GS and by 18,000 miles it had needed about £1500 of repairs, luckily all but £200 under warranty, but it seemed there was always something not right with the bike at any one time, and the latest model has had more than its fair share of exploded / engines / clutches / gearboxes - but I am sure it rides real well, I think BMW do build amazing road bikes - just they build them badly (IMO)
A mate of mine has the Explorer, it too has had a lot of work done (Cylinder Head / Final Drive Assembly and Engine Management System) in 2 years / 5,000 miles - but I understand they are generally OK once the initial bugs have been sorted.
I think the S10 is the best long term prospect as long your not bothered about performance over 100mph, it is fast enough up to 3 figure speeds, comfy and handles far better than a bike of its weight should do.
It works well on all roads being comfy on motorways, handling well on good sweeping A-Roads, and being a joy on tight mountain switchbacks, it will also handle bumpy back lanes / gravel tracks or anything else you encounter or are skilled enough to tackle.
it is not hard or overly expensive to pick up a bit more power with a different exhaust / flash if you feel the need, but will still be behind the likes of the Multistrada by quite a margin, but I am glad I had some work done to boost mine a little bit.
I do plan to buy a "Modern Classic" sportsbike at some point to scratch the speed itch once in a while.