I came over from a DL650, and haven't ever looked back. The Super Tenere is a lot like a DL650 on steroids; there's just more of what you liked about the V-Strom. The weight has never been an issue to me; it weighs more on paper than a V-Strom, but with a full tank of gas, my V-Strom felt like the heavier bike. The V-Strom may have been more "flickable", but the Super Tenere feels more planted, which is an important factor if you do a lot of commuting on interstate highways with lots of big trucks around. Brakes and suspension are much better on the S10. I prefer the shaft drive to a chain. The S10 has higher valve check interval than the V-Strom (26,000 vs 17,000). Around 30 extra HP on the S10, which is also helpful if your commute is on the interstates. MPG is less on the S10: I get around 45 mpg in the summer, and it was about 50-51mpg on the V-Strom. The S10 engine has a very different feel to it than the V-Strom. It revs lower, and some people describe it as "tractor-like". I didn't feel that way. It feels different, but not worse. It's very roomy, if you travel with a passenger. I had a Harley Road King at one time, and my usual passenger says she has a lot more room on the S10 than she did on the Harley, and it's more comfortable. She told me it's more roomy and comfortable that the V-Strom, too. The stock seat on the S10 is more comfortable that the V-Strom, though that isn't saying a whole lot.
I bought my 2014 brand new. It now has just shy of 44,000 miles on it. In that time, the only thing I've had to actually fix (that wasn't routine maintenance) were two burned out headlight bulbs. I've done all the maintenance myself (oil changes, fork oil changes, brake pads, brake/clutch fluid flushes, tire changes, etc) with the exception of the first valve check, and I'm no mechanic. Maintenance is straightforward. Believe me, lifting the tank on the S10 is WAY easier than doing it on the V-Strom.
The DL650 is an excellent bike, and I wouldn't bad-mouth it for a second. I just like my S10 even more.