What do you like? Camping or interrupting days in the saddle with evenings at an opera? Quiet motels or big name chain places, like a Fairfield or Marriott? Dirt & gravel, staying on 2 lane, or moving between destinations on the slab?
For riding alone, just go onto Google Maps and follow the green up along the Appalachians. If you've never done the length of the BRP and Skyline Drive, plan two days and enjoy. From the end, head up 219 through MD & PA, then follow the green on the map again. Maybe see Antiedam and Gettysburg battlefields. Lots of covered bridges and history. Head north through PA & NY to the finger lakes. You could even lap Lake Ontario and see the falls, head east till you hit salty water, then come south.