I rode it on two separate occasions. I was seriously contemplating replacing my 07 CBR600RR with the Tuono, but ended up buying the S10 instead. It was a combination of things, mostly fear of Italian things and the need for a bike that will go more than 100 miles on a tank and get better than 30mpg.
But, I have to tell you, I came so close to buying the Tuono that I surprised even myself. I would have one now if the current/recent price reduction was occuring when I rode it. The bike is magnificant. The sound alone is worth the price of admission. I've ridden a lot of bikes, but the Tuono V4 is hands down the most amazing sounding bike I've ever ridden. Even stock, it's loud, ballsy, and just plain awesome.
I think I got the very complicated APRC stuff to give me the right TC, wheelie, and power levels to let me sample full power safely without the fear of huge wheelies. By the end of the second demo ride, I was comfy enough to aggressively launch the bike from a red light and hit WOT to 60. It sort of takes the challenge out, but the quickshifter and the absolute speed mitigate the lack of challenge. Otherwise, the bike is as you'd expect. Stupidly fast, very slick, and with excellent (if not on par with Ducati monobloc) brakes. Sadly, no ABS.
The bike always seemed to be running into the TC/Wheelie nanny when I was caning it, but it was relatively unobtrusive. I could watch the lights come on as I went WOT in 3rd gear. And I could see the lights flash as the front end came up minimally between shifts. Anyway, it's a beast, but it is so easy to ride. I made a point to ride it like I usually ride when just bombing around. It's smooth and easy to ride slow. The power from low rpms (not lugging) is fine and the bike appears completely content to just cruise around.