Most motorcycle tuners delete the O2 sensors and richen the fuel table to maximise power on the dyno, which is a perfectly legitimate approach, but not the only one. However, using a PV3, I have found that my ST runs better with the O2 sensors and the tune developed by Hulkss (
https://yamahasupertenere.com/index.php?threads/tuning-with-the-power-vision-3.32372/) than any open loop map I have tried. I suspect that even proper remapping can be subject to expectation bias, in that you are absolutely convinced of the improvements after you have paid for it, but you are unable to revert back to confirm this. Many of us simply open the throttle more to demonstrate to ourselves just how much more powerful the bike is after remapping! Hilltop exploited this bias by actually doing nothing, yet riders were absolutely convinced and posted glowing testimonials on bike forums, which only served to confirm the opinions of everyone who had been there, like one big echo chamber (aided and abetted by the man himself!).
Having tried multiple changes to the various parameters in the ST ecu, the big improvements come from throttle, acceleration enrichment, timing, engine braking and deceleration fuel cut tables (not the fuel tables).
Chris put an open loop map built on the dyno for another ST onto my last bike and I felt that it improved the bike significantly. Although I have no way of comparing that tune to the one on my current bike, the present combination of easy throttle control, quite vicious acceleration in 3rd, 4th and 5th, and almost 63 mpg is quite astonishing.